Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10743840 | 0.77 | KMT2A (0.64) | PKMKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2113108 | 0.73 | ALDH1A1 (0.57) | KMT2AMEN1ALDH1A1MAPTTSHR | |
| SCHEMBL1308098 | 0.73 | GRIK1 (0.55) | GAAPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL27287798 | 0.72 | POLB (0.59) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL23040849 | 0.72 | KMT2A (0.57) | PKMKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29417331 | 0.72 | KMT2A (0.57) | PKMKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7308406 | 0.71 | TSHR (0.59) | KMT2AMEN1ALDH1A1MAPTTSHR | |
| SCHEMBL6691256 | 0.71 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1MAPTTSHR | |
| SCHEMBL1859781 | 0.70 | GAA (0.69) | GAAPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL27291409 | 0.70 | KCNK3 (0.54) | GAAKMT2AMEN1RXFP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940792-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-1 AND/OR PIM-3 | Exelixis, Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007044724-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-I AND/OR PIM-3 | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |