Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602080 | 1.00 | HTR2A (0.52) | HTR2AOPRM1SLC6A2SLC6A3CHRNB2 | |
| SCHEMBL4602093 | 1.00 | HTR2A (0.52) | HTR2AOPRM1SLC6A2SLC6A3CHRNB2 | |
| SCHEMBL440317 | 0.83 | DRD2 (0.54) | HTR2ASLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL440316 | 0.83 | DRD2 (0.54) | HTR2ASLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL2159303 | 0.83 | SLC6A3 (0.41) | HTR2ASLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL656206 | 0.83 | DRD2 (0.54) | HTR2ASLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL10169493 | 0.80 | DRD2 (0.37) | HTR2ASLC6A2SLC6A3SLC6A4DRD2 | |
| SCHEMBL27654547 | 0.79 | HTR2A (0.35) | HTR2AOPRM1SLC6A2SLC6A3ALDH1A1 | |
| Propionic Acid SCHEMBL2795314 | 0.77 | DRD2 (0.44) | SLC6A2SLC6A3ALDH1A1SLC6A4DRD2 | |
| SCHEMBL13282640 | 0.73 | SLC6A2 (0.42) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4651954-A1 | INHIBITORS OF MPTP | NRG Therapeutics LTD (GB) | 2025-11-26 | — | — | EP | disclosed |
| WO-2024153945-A1 | INHIBITORS OF MPTP | NRG THERAPEUTICS LTD (GB) | 2024-07-25 | — | — | WO | disclosed |
| EP-1912968-A1 | PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS | Pfizer Limited (GB) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015162-A1 | PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS | PFIZER LIMITED (GB) | 2007-02-08 | — | — | WO | disclosed |