Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 20/20 | 0.56 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951018 | 0.88 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4950481 | 0.85 | GABRG2 (0.58) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4948510 | 0.84 | GABRG2 (0.48) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4946718 | 0.84 | GABRG2 (0.47) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4950870 | 0.83 | GABRG2 (0.61) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4946797 | 0.82 | GABRG2 (0.48) | GABRG2GABRB3GABRA5 | |
| SCHEMBL4952206 | 0.79 | GABRG2 (0.47) | GABRG2GABRB3GABRA5 | |
| SCHEMBL3570896 | 0.79 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRPGABRD | |
| SCHEMBL3567727 | 0.73 | GABRG2 (0.79) | GABRG2GABRB3GABRA5GABRPGABRD | |
| SCHEMBL3884039 | 0.73 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828194-B1 | TETRACYCLIC IMIDAZO-BENZODIAZEPINES AS GABA RECEPTORS MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-05-28 | — | — | EP | disclosed |