Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31014028 | 0.79 | ABCB1 (0.49) | ABCB1ABCC1ABCG2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5239908 | 0.77 | ALDH1A1 (0.52) | ABCB1ABCC1ABCG2ALDH1A1LMNA | |
| SCHEMBL10383284 | 0.76 | ABCB1 (0.74) | ABCB1ABCC1ABCG2SMN1; SMN2KDM4E | |
| SCHEMBL5243392 | 0.76 | ABCB1 (0.46) | ABCB1ABCC1ABCG2ALDH1A1SMN1; SMN2 | |
| SCHEMBL30550477 | 0.75 | SIGMAR1 (0.54) | ALDH1A1SMN1; SMN2KDM4EDRD4LMNA | |
| SCHEMBL18356020 | 0.75 | SIGMAR1 (0.51) | ALDH1A1SMN1; SMN2DRD4DRD3KMT2A | |
| SCHEMBL382900 | 0.74 | ABCB1 (0.64) | ABCB1ABCC1ABCG2SMN1; SMN2KDM4E | |
| SCHEMBL1002978 | 0.74 | MEN1 (0.45) | ALDH1A1SMN1; SMN2LMNAPOLBMAPK1 | |
| SCHEMBL5243101 | 0.73 | ABCB1 (0.44) | ABCB1ABCC1ABCG2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5245082 | 0.71 | KDM4E (0.40) | ALDH1A1SMN1; SMN2KDM4EDRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912940-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007021309-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |