Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28617751 | 0.96 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL28613806 | 0.91 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL2747664 | 0.88 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL1697463 | 0.88 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL5259296 | 0.88 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL1697444 | 0.85 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL11196778 | 0.81 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL28893940 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL7429992 | 0.80 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPSR1 | |
| SCHEMBL809457 | 0.79 | PREP (0.64) | SMN1; SMN2KDM4ENPSR1L3MBTL1SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912662-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007016364-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |