Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143107 | 0.90 | MAPK14 (0.55) | MAPK14MAPK11ERBB2MAPK13MAPT | |
| SCHEMBL4602560 | 0.88 | RAB9A (0.47) | MAPK14MAPK11ERBB2MAPK13MAPT | |
| SCHEMBL4602913 | 0.85 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL4602180 | 0.85 | MAPK14 (0.53) | MAPK14MAPK11ERBB2MAPK13MAPT | |
| SCHEMBL2950787 | 0.85 | MAPK14 (0.56) | MAPK14MAPK13 | |
| SCHEMBL4602849 | 0.83 | MAPK14 (0.52) | MAPK14NTRK1MAPK11ERBB2MAPK13 | |
| SCHEMBL4615515 | 0.82 | MAPK14 (0.50) | MAPK14NTRK1MAPK11ERBB2MAPK13 | |
| SCHEMBL2950992 | 0.80 | MAPK14 (0.58) | MAPK14MAPK11ERBB2MAPK13MAPT | |
| SCHEMBL4603906 | 0.80 | MAPK14 (0.55) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL2948049 | 0.80 | MAPK14 (0.49) | MAPK14MAPK11ERBB2MAPK13MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |