Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953808 | 0.92 | MAPK14 (0.48) | MAPK14MAPK13FAAHMAPK11MAPK12 | |
| SCHEMBL6143107 | 0.90 | MAPK14 (0.55) | MAPK14MAPK13LMNAMAPK11MAPK12 | |
| SCHEMBL4604121 | 0.87 | MAPK14 (0.53) | MAPK14MAPK13LMNAABL1MAPK11 | |
| SCHEMBL4602180 | 0.85 | MAPK14 (0.53) | MAPK14MAPK13LMNAMAPK11MAPK12 | |
| SCHEMBL2951220 | 0.85 | MAPK14 (0.49) | MAPK14MAPK13LMNA | |
| SCHEMBL2950787 | 0.83 | MAPK14 (0.56) | MAPK14MAPK13LMNA | |
| SCHEMBL2948049 | 0.83 | MAPK14 (0.49) | MAPK14MAPK13LMNAMAPK11MAPK12 | |
| SCHEMBL4602560 | 0.81 | RAB9A (0.47) | MAPK14MAPK13LMNAMAPK11MAPK12 | |
| SCHEMBL2950992 | 0.80 | MAPK14 (0.58) | MAPK14MAPK13LMNAMAPK11MAPK12 | |
| SCHEMBL4602299 | 0.80 | MAPK14 (0.47) | MAPK14MAPK13MAPK11MAPK12ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |