Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18423170 | 0.86 | KDM4E (0.67) | ALDH1A1KDM4EHTTRXFP1KMT2A | |
| SCHEMBL6794867 | 0.79 | PARP1 (0.65) | ALDH1A1KMT2AMEN1TNKS2SMN1; SMN2 | |
| SCHEMBL9178009 | 0.79 | KMT2A (1.00) | ALDH1A1KDM4EKMT2AMEN1TNKS2 | |
| SCHEMBL13363211 | 0.78 | PDE9A (0.59) | ALDH1A1KDM4EKMT2AMEN1TNKS2 | |
| SCHEMBL23749827 | 0.78 | KMT2A (0.65) | ALDH1A1KDM4EHTTRXFP1KMT2A | |
| SCHEMBL30120622 | 0.78 | KMT2A (0.65) | ALDH1A1KDM4EHTTRXFP1KMT2A | |
| SCHEMBL11288070 | 0.77 | PDE10A (0.74) | KMT2ATNKS2PARP1 | |
| SCHEMBL29764103 | 0.77 | PDE10A (0.74) | KMT2ATNKS2PARP1 | |
| SCHEMBL30176850 | 0.77 | TNKS2 (1.00) | ALDH1A1KDM4EKMT2AMEN1TNKS2 | |
| SCHEMBL3826724 | 0.77 | TNKS2 (1.00) | ALDH1A1KDM4EKMT2AMEN1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790474-B1 | p53 modulators | SCHERING CORPORATION (US) | 2010-09-07 | — | — | US | disclosed |
| US-7790474-B1 | p53 modulators | SCHERING CORPORATION (US) | 2010-09-07 | — | — | US | disclosed |
| CN-101263124-A | Quinazoline derivatives useful in cancer treatment | SCHERING CORP (US) | 2008-09-10 | — | — | CN | disclosed |
| EP-1915351-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007011618-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007011618-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-01-18 | — | — | US | disclosed |
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-01-18 | — | — | US | disclosed |
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | TP53, TP53BP1, ACIN1 | ALDH1A1 1994/4885KDM4E 2378/4885HTT 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.