Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797440 | 0.84 | HTT (0.54) | TP53ALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL4603491 | 0.76 | SOS1 (0.36) | ALDH1A1MAPTGAAHPGD | |
| SCHEMBL3796969 | 0.75 | HTT (0.47) | MAPTGAAHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL3804143 | 0.75 | HTT (0.45) | TP53MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL3802155 | 0.74 | HTT (0.44) | TP53MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL13434843 | 0.72 | HTT (0.54) | TP53ALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL3799077 | 0.72 | PIP4K2C (0.46) | HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3799585 | 0.72 | RAB9A (0.47) | MAPTGAAHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL3796872 | 0.72 | RAB9A (0.47) | MAPTGAAHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL3805579 | 0.72 | MAPT (0.53) | TP53ALDH1A1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899353-A1 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | DeveloGen Aktiengesellschaft (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136402-A1 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2006-12-28 | — | — | WO | disclosed |