Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797145 | 0.86 | MKNK1 (0.44) | MKNK1MKNK2MAPTEIF4EIRAK4 | |
| SCHEMBL3795962 | 0.86 | MKNK1 (0.44) | MKNK1MKNK2MAPTEIF4EIRAK4 | |
| SCHEMBL3795968 | 0.86 | MKNK1 (0.44) | MKNK1MKNK2MAPTEIF4EIRAK4 | |
| SCHEMBL3798481 | 0.80 | MKNK2 (0.47) | MKNK1MKNK2MAPTIRAK4SRC | |
| SCHEMBL3795880 | 0.76 | MKNK2 (0.49) | MKNK1MKNK2EIF4ESRC | |
| SCHEMBL4602472 | 0.76 | TP53 (0.47) | ALDH1A1GAAMAPTHPGD | |
| SCHEMBL3804308 | 0.76 | MKNK2 (0.56) | MKNK1MKNK2EIF4E | |
| SCHEMBL3804173 | 0.74 | MKNK2 (0.42) | MKNK1MKNK2MAPTEIF4ESRC | |
| SCHEMBL3793904 | 0.72 | MAPK1 (0.50) | MKNK1MKNK2ALDH1A1GAAMAPT | |
| SCHEMBL3793898 | 0.72 | MAPK1 (0.50) | MKNK1MKNK2ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899353-A1 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | DeveloGen Aktiengesellschaft (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136402-A1 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2006-12-28 | — | — | WO | disclosed |