Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3184690 | 0.78 | CYP1A2 (0.47) | SLC6A2CYP2D6SLC6A4SLC6A3DPP4 | |
| SCHEMBL2785442 | 0.76 | DPP4 (0.47) | CYP2D6DPP4ALOX5APFEN1 | |
| SCHEMBL4624980 | 0.72 | MAPT (0.44) | CA12CA1CA2CA9 | |
| SCHEMBL8029374 | 0.72 | CA12 (0.38) | PTGS2DPP4CA12CA1CA2 | |
| SCHEMBL2787849 | 0.72 | DPP4 (0.50) | DPP4 | |
| SCHEMBL399409 | 0.70 | DPP4 (0.72) | DPP4 | |
| SCHEMBL3786432 | 0.70 | DPP4 (0.48) | DPP4LTB4R2 | |
| SCHEMBL6048541 | 0.70 | PTGS2 (0.59) | SLC6A4PTGS2 | |
| SCHEMBL8487915 | 0.69 | PTGS2 (0.75) | PTGS2 | |
| SCHEMBL7058631 | 0.69 | HSPA5 (0.45) | CYP2D6CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667647-A4 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1667647-A2 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005032468-A2 | MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-14 | — | — | WO | disclosed |