Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11800704 | 0.84 | SETD7 (0.47) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL11811607 | 0.83 | SETD7 (0.58) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL7306252 | 0.80 | SETD7 (0.59) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL7306260 | 0.80 | SETD7 (0.59) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL9455504 | 0.80 | SETD7 (0.68) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL11804707 | 0.80 | SETD7 (0.43) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| Hydrochloric Acid SCHEMBL7295701 | 0.79 | SETD7 (0.58) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| Hydrochloric Acid SCHEMBL7295705 | 0.79 | SETD7 (0.58) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL11626411 | 0.78 | ADRA1D (0.42) | SETD7DRD2ADRA1DADRA1AADRA2A | |
| SCHEMBL11806400 | 0.78 | ADRA1D (0.42) | SETD7DRD2ADRA1DADRA1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10398687-B2 | Use of cyproheptadine to treat organophosphate exposure | REPURPOSED THERAPEUTICS, INC. | 2019-09-03 | — | — | US | disclosed |
| US-20120065194-A1 | USE OF CYPROHEPTADINE TO TREAT ORGANOPHOSPHATE EXPOSURE | REPURPOSED THERAPEUTICS, INC. | 2012-03-15 | — | — | US | disclosed |
| US-4089864-A | 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines | MERCK & CO., INC. (US) | 1978-05-16 | — | — | US | disclosed |
| US-3988342-A | TRANQUILIZERS | MERCK & CO., INC. (US) | 1976-10-26 | — | — | US | disclosed |
| US-3981877-A | APPETITE STIMULANTS | MERCK & CO., INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3981876-A | ANTIHISTAMINES, APPETITE STIMULANTS | MERCK & CO., INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3968115-A | OR 11)-BROMO-10,11-DIHYDRO-5H-DIBENZO(A,D)-CYCLOHEPTEN-5-YLIDENE PIPERIDINE COMPOUNDSANTIHISTAMINE, APPETITE STIMULANT | MERCK & CO., INC. (US) | 1976-07-06 | — | — | US | disclosed |
| US-3960872-A | ANTIHISTAMINES, APPETITE STIMULANT | MERCK & CO., INC. (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065194-A1 | USE OF CYPROHEPTADINE TO TREAT ORGANOPHOSPHATE EXPOSURE | BCHE, ACHE, DDT | SETD7 4159/4885DRD2 272/4885ADRA1D 231/4885 |
| US-10398687-B2 | Use of cyproheptadine to treat organophosphate exposure | BCHE, ACHE, DDT | SETD7 4159/4885DRD2 272/4885ADRA1D 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.