Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | GGT1 | P19440 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1262963 | 1.00 | GRM2 (0.35) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL160649 | 0.78 | GGT1 (0.45) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL14923287 | 0.78 | GRM2 (0.36) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL10068450 | 0.78 | GRM2 (0.36) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL1262966 | 0.78 | GRM2 (0.36) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL7122883 | 0.78 | GRM2 (0.36) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL20049737 | 0.78 | GRM2 (0.36) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL181332 | 0.78 | GGT1 (0.45) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL160650 | 0.78 | GGT1 (0.45) | GRM2GRM3MMP8CYP2C19GGT1 | |
| SCHEMBL23376685 | 0.76 | GRM2 (0.35) | GRM2GRM3MMP8CYP2C19GGT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768978-B1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-07-09 | — | — | EP | disclosed |