Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5561550 | 1.00 | REN (0.70) | RENCYP3A4ACHE | |
| SCHEMBL6043442 | 0.92 | REN (0.74) | RENCYP3A4 | |
| SCHEMBL4603776 | 0.91 | REN (0.69) | RENCYP3A4ACHE | |
| SCHEMBL6958042 | 0.91 | REN (0.69) | RENCYP3A4ACHE | |
| SCHEMBL5798925 | 0.89 | REN (0.57) | RENCYP3A4ACHE | |
| SCHEMBL5798922 | 0.89 | REN (0.57) | RENCYP3A4ACHE | |
| SCHEMBL5563338 | 0.88 | REN (0.56) | RENCYP3A4 | |
| SCHEMBL5562042 | 0.88 | REN (0.54) | RENACHE | |
| SCHEMBL5561717 | 0.87 | REN (0.53) | REN | |
| SCHEMBL5561276 | 0.87 | REN (0.54) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| EP-1180103-B1 | RENIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-05-30 | — | — | EP | disclosed |
| EP-1180103-A1 | RENIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-20 | — | — | EP | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| US-6197959-B1 | CARDIOVASCULAR AND KIDNEY DISORDERS; RESTENOSIS, GLAUCOMA; HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-06 | — | — | US | disclosed |
| WO-2000064887-A1 | RENIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-11-02 | — | — | WO | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |