Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29798131 | 0.94 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7211275 | 0.94 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30683833 | 0.93 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321654 | 0.89 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6829290 | 0.89 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL26372 | 0.89 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL27516 | 0.89 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 0.89 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL13777301 | 0.89 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL5975855 | 0.89 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1941263-A1 | OPTICAL SEMI-QUANTITATIVE 100 % FILLING CHECK OF PHARMACEUTICAL CAPSULES ON CAPSULE FILLING MACHINES | Boehringer Ingelheim International GmbH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1901776-A1 | NOVEL MEDICINAL COMBINATIONS WHICH ARE USED FOR TREATING RESPIRATORY TRACT DISEASES AND CONTAIN BETA-2 LONG-ACTING AGONISTS AND AT LEAST ONE OTHER TYPE OF ACTIVE SUBSTANCE | Boehringer Ingelheim International GmbH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1789405-A1 | NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-30 | — | — | EP | disclosed |
| WO-2007045670-A1 | OPTICAL SEMI-QUANTITATIVE 100 % FILLING CHECK OF PHARMACEUTICAL CAPSULES ON CAPSULE FILLING MACHINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007003554-A1 | NOVEL MEDICINAL COMBINATIONS WHICH ARE USED FOR TREATING RESPIRATORY TRACT DISEASES AND CONTAIN BETA-2 LONG-ACTING AGONISTS AND AT LEAST ONE OTHER TYPE OF ACTIVE SUBSTANCE. | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-11 | — | — | WO | disclosed |
| WO-2005111005-A1 | NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |