Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817720 | 0.90 | PDE4B (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7112656 | 0.90 | PDE4B (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6820431 | 0.90 | PDE4B (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6819663 | 0.90 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321654 | 0.90 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| Bicarbonate SCHEMBL4603657 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7197733 | 0.87 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 0.87 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL26372 | 0.87 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Cilomilast SCHEMBL13777301 | 0.87 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200388-A4 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6740765-B1 | DECARBOXYLATING DIESTER | SMITHKLINE BEECHAM CORPORATION | 2004-05-25 | — | — | US | disclosed |
| EP-1200388-A1 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SmithKline Beecham Corporation (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001010817-A1 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-15 | — | — | WO | disclosed |