Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.57 |
| ▸ | MEN1 | O00255 | 12/20 | 0.57 |
| ▸ | POLB | P06746 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19652009 | 0.75 | MAPT (0.58) | MAPTALDH1A1NPSR1GFERKMT2A | |
| SCHEMBL12963896 | 0.74 | KMT2A (0.78) | MAPTALDH1A1NPSR1GFERKMT2A | |
| SCHEMBL8190455 | 0.73 | MAPT (0.66) | MAPTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8191326 | 0.73 | MAPT (0.66) | MAPTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8190456 | 0.73 | MAPT (0.66) | MAPTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL4604008 | 0.72 | MAPT (0.57) | MAPTALDH1A1NPSR1GFERKMT2A | |
| SCHEMBL46546 | 0.72 | MAPT (0.57) | MAPTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL13587009 | 0.71 | ALDH1A1 (0.72) | MAPTALDH1A1NPSR1GFERKMT2A | |
| SCHEMBL17717968 | 0.71 | CA12 (0.71) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL11908274 | 0.70 | KMT2A (0.63) | MAPTALDH1A1NPSR1GFERKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269252-A1 | Use of Compounds Derived From Pyrimidinetrione as Acetyl Cholinesterase Inhibitors, Compositions Containing Said Derivatives, and the Uses Thereof | CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-10-30 | — | — | US | claimed |
| EP-1845781-B1 | USE OF COMPOUNDS DERIVED FROM PYRIMIDINETRIONE AS ACETYL CHOLINESTERASE INHIBITORS, COMPOSITIONS CONTAINING SAID DERIVATIVES, AND THE USES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2008-07-09 | — | — | EP | claimed |
| US-8309556-B2 | Insecticides, neurodegenerative diseases; Alzheimer's disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-11-13 | — | — | US | disclosed |
| US-20080269252-A1 | Use of Compounds Derived From Pyrimidinetrione as Acetyl Cholinesterase Inhibitors, Compositions Containing Said Derivatives, and the Uses Thereof | CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-10-30 | — | — | US | disclosed |
| EP-1845781-B1 | USE OF COMPOUNDS DERIVED FROM PYRIMIDINETRIONE AS ACETYL CHOLINESTERASE INHIBITORS, COMPOSITIONS CONTAINING SAID DERIVATIVES, AND THE USES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2008-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269252-A1 | Use of Compounds Derived From Pyrimidinetrione as Acetyl Cholinesterase Inhibitors, Compositions Containing Said Derivatives, and the Uses Thereof | ACHE, BCHE, DPYD | MAPT 993/4885ALDH1A1 198/4885NPSR1 2658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.