SCHEMBL4603855

SCHEMBL4603855

CO[SiH](OC)C(Cl)CC1CC2C=CC1C2

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.37
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
HTT P42858 1/20 0.34
TSHR P16473 1/20 0.31
POLB P06746 1/20 0.30
ALOX15 P16050 1/20 0.30
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602403 0.84 KDM4E (0.39) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL7531435 0.75 KDM4E (0.43) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL14761258 0.74 KDM4E (0.34) KDM4EALDH1A1POLBALOX15
SCHEMBL465320 0.73 KDM4E (0.47) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL257634 0.73 KDM4E (0.41) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL19689430 0.70 KDM4E (0.44) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL6064173 0.70 KDM4E (0.42) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL14761128 0.70 KDM4E (0.40) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL6063081 0.69 KDM4E (0.38) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL11167124 0.69 KDM4E (0.38) KDM4EALDH1A1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1364975-B1 PROCESSES FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR CORP (JP) 2008-04-30 EP disclosed
US-20070225461-A1 Olefin polymers for imaging members LEXMARK INTERNATIONAL INC. 2007-09-27 US disclosed
US-6911507-B2 Processes for producing cycloolefin addition polymer JSR CORPORATION (JP) 2005-06-28 US disclosed
US-20040063873-A1 Processes for producing cycloolefin addition polymer JSR CORPORATION (JP) 2004-04-01 US disclosed
EP-1364975-A1 PROCESSES FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR Corporation (JP) 2003-11-26 EP disclosed