Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RBP4 | P02753 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827641 | 0.89 | KDM4E (0.51) | KDM4EHSD17B10RXFP1 | |
| SCHEMBL1826748 | 0.88 | KDM4E (0.50) | KDM4EHSD17B10RBP4CYP3A4CYP2C9 | |
| SCHEMBL1825088 | 0.87 | KDM4E (0.49) | KDM4EHSD17B10RBP4CYP3A4CYP2C9 | |
| SCHEMBL1825885 | 0.87 | KDM4E (0.49) | KDM4EHSD17B10RBP4CYP3A4CYP2C9 | |
| SCHEMBL4604582 | 0.85 | MAOB (0.53) | KDM4EHSD17B10MAOBMAOARBP4 | |
| SCHEMBL1827185 | 0.84 | KDM4E (0.50) | KDM4EHSD17B10POLB | |
| SCHEMBL4603406 | 0.83 | GAA (0.53) | KDM4EHSD17B10POLBRBP4CYP3A4 | |
| SCHEMBL1825725 | 0.82 | KDM4E (0.47) | KDM4EHSD17B10POLBRXFP1 | |
| SCHEMBL1826827 | 0.82 | KDM4E (0.50) | KDM4EHSD17B10RXFP1 | |
| SCHEMBL1824147 | 0.82 | KDM4E (0.47) | KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1914152-B | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB | 2010-06-09 | — | — | CN | claimed |
| EP-1720825-B1 | ANTHRANILIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE AS DHODH INHIBITORS | ACTIVE BIOTECH AB (SE) | 2008-07-09 | — | — | EP | claimed |
| CN-1914152-A | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2007-02-14 | — | — | CN | claimed |
| US-7074831-B2 | Compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2006-07-11 | — | — | US | claimed |
| US-20050187297-A1 | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2005-08-25 | — | — | US | claimed |
| US-20210379070-A1 | MALONATE SALT OF VARLITINIB | ASLAN PHARMACEUTICALS PTE LTD (SG) | 2021-12-09 | — | — | US | disclosed |
| US-10646478-B2 | Methods for treatment of melanoma | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2020-05-12 | — | — | US | disclosed |
| US-10016402-B2 | Methods for treatment of melanoma | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| CN-1914152-B | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB | 2010-06-09 | — | — | CN | disclosed |
| EP-1720825-B1 | ANTHRANILIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE AS DHODH INHIBITORS | ACTIVE BIOTECH AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| CN-1914152-A | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2007-02-14 | — | — | CN | disclosed |
| EP-1720825-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Active Biotech AB (SE) | 2006-11-15 | — | — | EP | disclosed |
| US-7074831-B2 | Compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2006-07-11 | — | — | US | disclosed |
| US-20050187297-A1 | New compounds, methods for their preparation and use thereof | ACTIVE BIOTECH AB (SE) | 2005-08-25 | — | — | US | disclosed |
| WO-2005075410-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | ACTIVE BIOTECH AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10646478-B2 | Methods for treatment of melanoma | DHODH, ALDH1A2, DLD | KDM4E 570/4885HSD17B10 261/4885MAOB 144/4885 |
| US-20210379070-A1 | MALONATE SALT OF VARLITINIB | KRAS, JAK1, JAK2 | KDM4E 663/4885HSD17B10 3268/4885MAOB 4700/4885 |
| US-20050187297-A1 | New compounds, methods for their preparation and use thereof | MALT1, TPMT, FUCA1 | KDM4E 2898/4885HSD17B10 783/4885MAOB 1445/4885 |
| US-10016402-B2 | Methods for treatment of melanoma | DHODH, ALDH1A2, DLD | KDM4E 570/4885HSD17B10 261/4885MAOB 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.