SCHEMBL4604288

SCHEMBL4604288

CCCCc1ccc(-c2ccccc2)c(-c2ccc(F)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PSMB5 P28074 1/20 0.53
HSD11B1 P28845 2/20 0.47
RARB P10826 5/20 0.45
LTB4R2 Q9NPC1 3/20 0.42
GPR3 P46089 1/20 0.41
MPL P40238 1/20 0.40
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
RARA P10276 1/20 0.39
RARG P13631 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11325207 0.91 PSMB5 (0.61) PSMB5HSD11B1RARBGPR3
SCHEMBL9617751 0.88 PSMB5 (0.51) PSMB5HSD11B1RARBLTB4R2GPR3
SCHEMBL9225803 0.84 PSMB5 (0.47) PSMB5HSD11B1RARBLTB4R2GPR3
SCHEMBL26193728 0.83 RARB (0.55) PSMB5HSD11B1RARBGPR3RARA
SCHEMBL5683080 0.82 RARB (0.46) PSMB5HSD11B1RARBLTB4R2GPR3
SCHEMBL21609936 0.81 HSD11B1 (0.59) PSMB5HSD11B1RARBMPLRARA
SCHEMBL29100401 0.80 CNR1 (0.48) PSMB5
SCHEMBL9223658 0.80 RARB (0.50) PSMB5HSD11B1RARBLTB4R2GPR3
SCHEMBL11512580 0.80 HSD11B1 (0.62) PSMB5HSD11B1RARBLTB4R2RARA
SCHEMBL8990707 0.80 RARB (0.56) RARBMPLFFAR1FFAR4RARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680482-B1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING (US) 2008-10-08 EP disclosed
EP-1682632-B1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING (US) 2008-07-09 EP disclosed
US-20070003702-A1 Method of preparing a metal-silicone rubber composite DOW CORNING CORPORATION 2007-01-04 US disclosed
EP-1689906-A1 METHOD OF PREPARING A METAL-SILICONE RUBBER COMPOSITE Dow Corning Corporation (US) 2006-08-16 EP disclosed
EP-1682632-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL Dow Corning Corporation (US) 2006-07-26 EP disclosed
EP-1680482-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL Dow Corning Corporation (US) 2006-07-19 EP disclosed
WO-2005056871-A1 METHOD OF PREPARING A METAL-SILICONE RUBBER COMPOSITE DOW CORNING CORPORATION (US) 2005-06-23 WO disclosed
WO-2005044950-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING CORPORATION (US) 2005-05-19 WO disclosed
WO-2005044949-A1 SILICONE COMPOSITION AND POLYMER DISPERSED LIQUID CRYSTAL DOW CORNING CORPORATION (US) 2005-05-19 WO disclosed