Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16534080 | 0.89 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1GSK3BLMNA | |
| SCHEMBL5555427 | 0.87 | PRKAG1 (0.46) | KDM4ESMN1; SMN2GSK3BWNT1DYRK1A | |
| SCHEMBL4604232 | 0.80 | KDM4E (0.52) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1636035 | 0.75 | KDM4E (0.66) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4101185 | 0.73 | KDM4E (0.68) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5555429 | 0.72 | DYRK1A (0.36) | KDM4ESMN1; SMN2GSK3BWNT1DYRK1A | |
| SCHEMBL5922444 | 0.72 | KDM4E (0.66) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL960087 | 0.72 | KDM4E (0.66) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31507475 | 0.71 | KDM4E (0.64) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL493081 | 0.71 | KDM4E (0.64) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |