Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 9/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 9/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 8/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 8/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 8/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | WNT1 | P04628 | 4/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16534080 | 0.89 | KDM4E (0.47) | PRKAG1PRKAA1PRKAB1HAO1GSK3B | |
| SCHEMBL4604844 | 0.87 | KDM4E (0.51) | GSK3BDYRK1AWNT1KDM4ESMN1; SMN2 | |
| SCHEMBL4604266 | 0.78 | PRKAG1 (0.44) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL5550310 | 0.77 | DYRK1A (0.44) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL5555429 | 0.76 | DYRK1A (0.36) | PRKAG1PRKAA1PRKAB1GSK3BDYRK1A | |
| SCHEMBL6598584 | 0.75 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL16517744 | 0.72 | RIPK1 (0.33) | GSK3B | |
| SCHEMBL5554387 | 0.70 | DYRK1A (0.43) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL4604091 | 0.70 | CHRNA7 (0.58) | — | |
| SCHEMBL28811273 | 0.68 | PRKAG1 (0.43) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185187-A1 | INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185187-A1 | INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA | CYP3A43, CYP3A5, SIRT5 | PRKAG1 4426/4885PRKAA1 2207/4885PRKAB1 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.