Styrene

Styrene

SCHEMBL4605348

C=Cc1ccccc1.C=Cc1nc(N)nc(N)n1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.56
TSHR P16473 1/20 0.56
ADORA2A P29274 2/20 0.42
ADORA1 P30542 2/20 0.42
POLB P06746 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
ADORA2B P29275 1/20 0.42
HRH4 Q9H3N8 1/20 0.41
DHFR P00374 2/20 0.39
GRM4 Q14833 7/20 0.39
HDAC6 Q9UBN7 1/20 0.37
DCPS Q96C86 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP19A1 P11511 1/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL1975918 0.92 ALDH1A1 (0.67) ALDH1A1TSHRADORA2AADORA1POLB
Styrene SCHEMBL11320045 0.88 ALDH1A1 (0.61) ALDH1A1TSHRADORA2AADORA1POLB
Benzoguanamine SCHEMBL3422336 0.81 ADORA2A (0.70) ALDH1A1TSHRADORA2AADORA1POLB
SCHEMBL139174 0.80 LMNA (0.36)
SCHEMBL31006739 0.77 ADORA2A (0.64) ALDH1A1TSHRADORA2AADORA1POLB
SCHEMBL28773675 0.75 HRH4 (0.58) ALDH1A1HRH4DHFRGRM4HDAC6
SCHEMBL31484371 0.75 HRH4 (0.58) ALDH1A1HRH4DHFRGRM4HDAC6
Styrene SCHEMBL21485240 0.75 ALDH1A1 (0.88) ALDH1A1TSHRCYP19A1MAOAMAOB
Styrene SCHEMBL10892600 0.75 ALDH1A1 (1.00) ALDH1A1TSHRHDAC6SMN1; SMN2CYP19A1
Styrene SCHEMBL4986035 0.75 ALDH1A1 (1.00) ALDH1A1TSHRHDAC6SMN1; SMN2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1368413-B1 TWO-LAYER IMAGEABLE ELEMENT COMPRISING THERMALLY REVERSIBLE POLYMERS EASTMAN KODAK CO (US) 2008-07-23 EP disclosed
EP-1368412-B1 IMAGEABLE ELEMENT AND COMPOSITION COMPRISING THERMALLY REVERSIBLE POLYMERS EASTMAN KODAK CO (US) 2008-06-04 EP disclosed
CN-100344666-C Novel chain extenders for the production of polyurethanes and corresponding polyurethanes HUNTSMAN INT LLC (US) 2007-10-24 CN disclosed
EP-1368413-A4 TWO-LAYER IMAGEABLE ELEMENT COMPRISING THERMALLY REVERSIBLE POLYMERS KODAK POLYCHROME GRAPHICS LLC (US) 2006-08-02 EP disclosed
EP-1368412-A4 IMAGEABLE ELEMENT AND COMPOSITION COMPRISING THERMALLY REVERSIBLE POLYMERS KODAK POLYCHROME GRAPHICS LLC (US) 2006-07-19 EP disclosed
CN-1771272-A Novel chain extenders for the production of polyurethanes and corresponding polyurethanes HUNTSMAN INT LLC (US) 2006-05-10 CN disclosed
US-20060058493-A1 Novel chain extender useful in the manufacture of polyurethanes and the corresponding polyurethanes HUNTSMAN INTERNATIONAL LLC (US) 2006-03-16 US disclosed
US-6911296-B2 Heat sensititve element on substrate KODAK POLYCHROME GRAPHICS LLC (US) 2005-06-28 US disclosed
EP-1466932-A1 Chain extender useful in the manufacture of polyurethanes and the corresponding polyurethanes HUNTSMAN INTERNATIONAL LLC (US) 2004-10-13 EP disclosed
EP-1368413-A1 TWO-LAYER IMAGEABLE ELEMENT COMPRISING THERMALLY REVERSIBLE POLYMERS Kodak Polychrome Graphics (US) 2003-12-10 EP disclosed
EP-1368412-A1 IMAGEABLE ELEMENT AND COMPOSITION COMPRISING THERMALLY REVERSIBLE POLYMERS Kodak Polychrome Graphics LLC (US) 2003-12-10 EP disclosed
US-20030129506-A1 Heat sensititve element on substrate KODAK POLYCHROME GRAPHICS, L.L.C. 2003-07-10 US disclosed
US-20020160299-A1 Polyurethanes KODAK POLYCHROME GRAPHICS, L.L.C. (US) 2002-10-31 US disclosed
WO-2002053627-A1 TWO-LAYER IMAGEABLE ELEMENT COMPRISING THERMALLY REVERSIBLE POLYMERS KODAK POLYCHROME GRAPHICS, L.L.C. (US) 2002-07-11 WO disclosed
WO-2002053626-A1 IMAGEABLE ELEMENT AND COMPOSITION COMPRISING THERMALLY REVERSIBLE POLYMERS KODAK POLYCHROME GRAPHICS, L.L.C. (US) 2002-07-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020160299-A1 Polyurethanes PUF60, PCBP1, PARG ALDH1A1 2144/4885TSHR 4885/4885ADORA2A 4821/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.