Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377975 | 0.83 | PARP1 (0.51) | BRD4BAZ2BBAZ2ASMN1; SMN2HSD11B1 | |
| SCHEMBL10421098 | 0.78 | CNR2 (0.45) | SMN1; SMN2HSD11B1HIF1ANPSR1RXFP1 | |
| SCHEMBL12852653 | 0.77 | SMN1; SMN2 (0.42) | FYNSMN1; SMN2CCR3HIF1ANPSR1 | |
| SCHEMBL20888384 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2CCR3HIF1ANPSR1RXFP1 | |
| SCHEMBL13151302 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2CCR3HIF1ANPSR1RXFP1 | |
| SCHEMBL12377870 | 0.75 | L3MBTL1 (0.62) | SMN1; SMN2NPSR1 | |
| SCHEMBL6706194 | 0.75 | SMN1; SMN2 (0.39) | KEAP1NFE2L2SMN1; SMN2HSD11B1HIF1A | |
| SCHEMBL14488498 | 0.73 | SYK (0.43) | CCR3 | |
| SCHEMBL4605605 | 0.73 | CCR3 (0.42) | SMN1; SMN2HSD11B1CCR3HIF1ANPSR1 | |
| SCHEMBL7452483 | 0.72 | ACLY (0.53) | SMN1; SMN2HSD11B1CCR3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943235-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Novartis AG (CH) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048771-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2007-05-03 | — | — | WO | disclosed |