Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6549653 | 0.79 | VCAM1 (0.49) | VCAM1TDP1CA1CA2CA12 | |
| SCHEMBL4607518 | 0.75 | VCAM1 (0.54) | VCAM1TDP1CA1CA2CA12 | |
| SCHEMBL4603369 | 0.75 | TDP1 (0.58) | VCAM1TDP1CA1CA2CA12 | |
| SCHEMBL21291911 | 0.69 | PARP1 (0.41) | TDP1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL27568410 | 0.69 | TDP1 (0.42) | VCAM1TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL1130962 | 0.68 | VCAM1 (0.53) | VCAM1TDP1CA1CA2CA12 | |
| SCHEMBL1857266 | 0.68 | MAPK1 (0.51) | VCAM1TDP1CA1CA2F2 | |
| SCHEMBL6936039 | 0.68 | TDP1 (0.43) | TDP1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL1865349 | 0.68 | MAPT (0.61) | VCAM1ALDH1A1MAPTLMNARAF1 | |
| SCHEMBL15328371 | 0.68 | ITGB1 (0.41) | VCAM1TDP1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265603-B1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1265603-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | EP | disclosed |
| US-6767922-B2 | ADMINISTERING N-(3-AMINOSULFONYL-2-HYDROXYPHENYL)-UREA DERIVATIVES; TREATMENT OF RESPIRATORY AND NERVOUS SYSTEM DISORDERS; ARTHRITIS, ASTHMA; VIRICIDES | SMITHKLINE BEECHAM CORPORATION | 2004-07-27 | — | — | US | disclosed |
| CN-1424910-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2003-06-18 | — | — | CN | disclosed |
| US-20030065188-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-04-03 | — | — | US | disclosed |
| EP-1265603-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068570-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065188-A1 | Il-8 receptor antagonists | CXCL8, CCR8, IL1RN | VCAM1 170/4885TDP1 4316/4885CA1 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.