Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606578 | 0.82 | HSD17B1 (0.51) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL28655414 | 0.75 | HSD17B1 (0.78) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL4608530 | 0.74 | GRIA4 (0.59) | HSD17B1 | |
| SCHEMBL4606554 | 0.71 | KDM1A (0.66) | CYP1A2HSD17B10MAOBMAOAKDM1A | |
| SCHEMBL1745161 | 0.71 | HSD17B1 (0.71) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL1030949 | 0.70 | HSD17B1 (1.00) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL30456099 | 0.70 | HSD17B1 (0.65) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL1747435 | 0.70 | HSD17B1 (0.69) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL28655417 | 0.70 | HSD17B1 (0.65) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 | |
| SCHEMBL1745120 | 0.70 | HSD17B1 (0.69) | HSD17B1CYP1A2CYP11B1CYP11B2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |