Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.66 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606611 | 1.00 | GRIA4 (0.66) | GRIA4GRIA2NPC1RAB9AKCNH2 | |
| SCHEMBL4607600 | 0.86 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4607075 | 0.86 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL3205615 | 0.85 | GRIA2 (0.49) | GRIA4GRIA2KCNH2 | |
| SCHEMBL3205619 | 0.85 | GRIA2 (0.49) | GRIA4GRIA2KCNH2 | |
| SCHEMBL3205609 | 0.85 | GRIA2 (0.49) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4606652 | 0.85 | GRIA4 (0.60) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4606949 | 0.85 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606558 | 0.85 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4607083 | 0.85 | GRIA4 (0.60) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |