Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556246 | 0.85 | HTR6 (0.56) | TSHRHTR2AHTR2CHTTHTR6 | |
| SCHEMBL13496586 | 0.81 | KDM4E (0.41) | TSHRKDM4EHTR2CALDH1A1MAPT | |
| SCHEMBL1827429 | 0.81 | SMN1; SMN2 (0.46) | TSHRKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL3462132 | 0.80 | HTR2A (0.44) | TSHRKDM4EHTR2AHTR2CHTT | |
| SCHEMBL5746662 | 0.74 | HTR1B (0.51) | KDM4EHTR2AHTR2CHTTHTR6 | |
| SCHEMBL20970934 | 0.74 | HTR6 (0.71) | TSHRKDM4EHTR2AHTR2CHTT | |
| SCHEMBL29536604 | 0.74 | HTR6 (0.71) | TSHRKDM4EHTR2AHTR2CHTT | |
| SCHEMBL14141474 | 0.73 | HTR6 (0.65) | TSHRKDM4EHTR2AHTR2CHTT | |
| SCHEMBL853973 | 0.71 | HTR2A (0.47) | KDM4EHTR2AHTR2CHTTALDH1A1 | |
| SCHEMBL5749322 | 0.70 | ABCG2 (0.59) | TSHRKDM4EHTR2AHTR2CHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1947085-A1 | Substituted indole sulfonamide compounds, their preparation and use as medicaments | Laboratorios del Dr. Esteve S.A. (ES) | 2008-07-23 | — | — | EP | disclosed |
| EP-1947085-A1 | Substituted indole sulfonamide compounds, their preparation and use as medicaments | Laboratorios del Dr. Esteve S.A. (ES) | 2008-07-23 | — | — | EP | disclosed |