Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564365 | 0.86 | SLC6A4 (0.43) | KDM4EHSD17B10HPGDALDH1A1KMT2A | |
| SCHEMBL13496586 | 0.84 | KDM4E (0.41) | SMN1; SMN2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL3461673 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2ALKKDM4EALDH1A1NPSR1 | |
| SCHEMBL4606783 | 0.81 | TSHR (0.49) | ALKKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3382239 | 0.75 | SLC6A4 (0.45) | SMN1; SMN2ALKKDM4EALDH1A1TDP1 | |
| SCHEMBL13463372 | 0.71 | ACHE (0.45) | SMN1; SMN2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL3563207 | 0.70 | HTR7 (0.60) | ALDH1A1KMT2ACYP1A2LMNAMAPT | |
| SCHEMBL1795017 | 0.70 | PARP1 (0.58) | SMN1; SMN2KDM4EKMT2ANPSR1CYP1A2 | |
| SCHEMBL3555772 | 0.69 | HTR6 (0.64) | KDM4EHSD17B10HPGDALDH1A1KMT2A | |
| SCHEMBL3462480 | 0.69 | SLC6A4 (0.42) | KDM4EHPGDALDH1A1NPSR1PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318397-A2 | SUBSTITUTED INDOLE SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010012806-A2 | SUBSTITUTED INDOLE SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | WO | disclosed |