Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607477 | 0.90 | GRIA4 (0.57) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607636 | 0.90 | GRIA4 (0.57) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605760 | 0.90 | GRIA4 (0.58) | GRIA4GRIA2KDM4EMEN1NPC1 | |
| SCHEMBL4605766 | 0.90 | GRIA4 (0.58) | GRIA4GRIA2KDM4EMEN1NPC1 | |
| SCHEMBL4605829 | 0.87 | GRIA4 (0.56) | GRIA4GRIA2MAOBKCNH2 | |
| SCHEMBL4607371 | 0.87 | GRIA4 (0.56) | GRIA4GRIA2MAOBKCNH2 | |
| SCHEMBL4607600 | 0.87 | GRIA4 (0.70) | GRIA4GRIA2MAOB | |
| SCHEMBL4607075 | 0.87 | GRIA4 (0.70) | GRIA4GRIA2MAOB | |
| SCHEMBL4605831 | 0.86 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605833 | 0.86 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |