Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607636 | 1.00 | GRIA4 (0.57) | GRIA4GRIA2KCNH2DGAT1ITGB3 | |
| SCHEMBL4606949 | 0.92 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606558 | 0.92 | GRIA4 (0.60) | GRIA4GRIA2 | |
| SCHEMBL4606805 | 0.90 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605829 | 0.89 | GRIA4 (0.56) | GRIA4GRIA2KCNH2ITGB3ITGB1 | |
| SCHEMBL4607371 | 0.89 | GRIA4 (0.56) | GRIA4GRIA2KCNH2ITGB3ITGB1 | |
| SCHEMBL4607075 | 0.89 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4607600 | 0.89 | GRIA4 (0.70) | GRIA4GRIA2 | |
| SCHEMBL4605833 | 0.88 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4605831 | 0.88 | GRIA4 (0.55) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |