Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362464 | 0.86 | LTA4H (0.56) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL7618233 | 0.85 | LTA4H (0.61) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL30932805 | 0.85 | MAPT (0.54) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL10945123 | 0.84 | FNTA (0.53) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL12879475 | 0.84 | FNTA (0.53) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL30337968 | 0.83 | MAPT (0.53) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4609415 | 0.83 | FNTA (0.52) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL21753952 | 0.81 | MEN1 (0.50) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL29395053 | 0.81 | LTA4H (0.62) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL166772 | 0.81 | MEN1 (0.50) | MEN1KMT2AMAPTPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |