Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519821 | 0.95 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3DDB1CRBN | |
| SCHEMBL5613574 | 0.93 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3DDB1CRBN | |
| SCHEMBL719480 | 0.77 | HTR2C (0.42) | DDB1CRBNTNKSTNKS2 | |
| Hydrochloric Acid SCHEMBL30656513 | 0.76 | HTR2C (0.44) | DDB1CRBNTNKSTNKS2 | |
| SCHEMBL512106 | 0.76 | SRD5A1 (0.41) | SLC6A2SLC6A4SLC6A3ALDH1A1HPGD | |
| SCHEMBL361341 | 0.76 | LMNA (0.43) | SLC6A2SLC6A4SLC6A3GAAALDH1A1 | |
| SCHEMBL4917555 | 0.76 | LIG1 (0.40) | GAACYP19A1MAPK1MEN1KMT2A | |
| SCHEMBL11637205 | 0.75 | DDB1 (0.55) | DDB1CRBNALDH1A1HPGDRAB9A | |
| SCHEMBL28745563 | 0.75 | ALDH1A1 (0.44) | DDB1CRBNGAAALDH1A1HPGD | |
| SCHEMBL361599 | 0.75 | DDB1 (0.48) | DDB1CRBNKMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |
| CN-87106830-A | TERTIARY AMINE COMPOUND | — | 1988-06-29 | — | — | CN | disclosed |
| EP-0259977-A2 | Tertiary amine compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-16 | — | — | EP | disclosed |