SCHEMBL4607665

SCHEMBL4607665

O=C(Cl)c1cccc2ccc3c4ccccc4cc(C(=O)Cl)c3c12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.50
ERBB2 P04626 1/20 0.50
FYN P06241 1/20 0.50
MAOA P21397 1/20 0.50
ACHE P22303 1/20 0.50
AHR P35869 1/20 0.50
ALDH1A1 P00352 7/20 0.41
HPGD P15428 4/20 0.41
MAPT P10636 1/20 0.41
SOS1 Q07889 1/20 0.41
HSD17B10 Q99714 4/20 0.41
THRB P10828 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
RXFP1 Q9HBX9 1/20 0.41
NR4A1 P22736 1/20 0.40
NR4A2 P43354 1/20 0.40
NR4A3 Q92570 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829025 0.83 NR4A1 (0.53) CYP1A2ERBB2FYNMAOAACHE
Hydrochloric Acid SCHEMBL4607669 0.81 NR4A1 (0.51) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL4607896 0.81 HSD17B10 (0.48) CYP1A2ALDH1A1HPGDMAPTHSD17B10
SCHEMBL9062637 0.76 HPRT1 (0.54) ALDH1A1HPGDMAPTSOS1HSD17B10
SCHEMBL21815744 0.76 MEN1 (0.50) CYP1A2ALDH1A1HPGDMAPTHSD17B10
SCHEMBL29868398 0.75 HSD17B10 (0.50) CYP1A2ALDH1A1HPGDMAPTHSD17B10
SCHEMBL1791928 0.75 HSD17B10 (0.50) CYP1A2ALDH1A1HPGDMAPTHSD17B10
SCHEMBL8854740 0.74 ALDH1A1 (0.50) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL28394503 0.72 ALDH1A1 (0.41) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL4607123 0.72 ALDH1A1 (0.57) CYP1A2ALDH1A1HPGDSOS1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945693-B1 POLYARYLATE-SILOXANE COPOLYMERS MOMENTIVE PERFORMANCE MAT INC (US) 2014-08-13 EP disclosed
EP-1957558-A2 POLYARYLATE ACID CHLORIDE COMPOSITIONS AND DERIVATES THEREFROM General Electric Company (US) 2008-08-20 EP disclosed
EP-1945693-A1 POLYARYLATE-SILOXANE COPOLYMERS Momentive Performance Materials Inc. (US) 2008-07-23 EP disclosed
WO-2007070377-A2 POLYARYLATE ACID CHLORIDE COMPOSITIONS AND DERIVATES THEREFROM GENERAL ELECTRIC COMPANY (US) 2007-06-21 WO disclosed
US-20070135610-A1 Polyarylate acid chloride compositions and derivatives therefrom GENERAL ELECTRIC COMPANY (US) 2007-06-14 US disclosed
WO-2007047083-A1 POLYARYLATE-SILOXANE COPOLYMERS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-04-26 WO disclosed
US-20070083026-A1 Polyarylate-siloxane copolymers GENERAL ELECTRIC COMPANY (US) 2007-04-12 US disclosed