Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 20/20 | 0.74 |
| ▸ | PDK2 | Q15119 | 20/20 | 0.74 |
| ▸ | PDK3 | Q15120 | 20/20 | 0.74 |
| ▸ | PDK4 | Q16654 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568377 | 0.91 | PDK1 (0.74) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608424 | 0.86 | PDK1 (0.63) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL25026296 | 0.85 | ALDH1A1 (0.55) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6348275 | 0.85 | PDK1 (1.00) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL31053831 | 0.85 | ALDH1A1 (0.55) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4610340 | 0.85 | PDK1 (0.73) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6348342 | 0.84 | PDK1 (0.76) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6348339 | 0.84 | PDK1 (0.76) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608920 | 0.83 | PDK1 (0.59) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608925 | 0.83 | PDK1 (0.59) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-B1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |