SCHEMBL4608027

SCHEMBL4608027

COc1cccc(O)c1C1CCCCC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.55
TP53 P04637 2/20 0.50
LMNA P02545 2/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
MAPK1 P28482 1/20 0.50
HSD17B10 Q99714 1/20 0.50
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
TSHR P16473 1/20 0.47
CNR2 P34972 6/20 0.46
CNR1 P21554 5/20 0.46
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5480007 0.98 ABCB1 (0.53) ABCB1TP53LMNAKDM4EALDH1A1
SCHEMBL2047875 0.91 TP53 (0.55) ABCB1TP53LMNAKDM4EALDH1A1
SCHEMBL19072578 0.87 ABCB1 (0.68) ABCB1TP53LMNAKDM4EALDH1A1
SCHEMBL7531576 0.81 HDAC4 (0.50) ABCB1LMNAKDM4EALDH1A1HPGD
SCHEMBL6004412 0.81 HDAC4 (0.50) ABCB1LMNAKDM4EALDH1A1HPGD
SCHEMBL28204910 0.81 ABCB1 (0.60) ABCB1CA1CA2MEN1KMT2A
SCHEMBL8784420 0.79 ABCB1 (0.55) ABCB1TP53KDM4EALDH1A1MAPT
SCHEMBL3169205 0.79 HDAC4 (0.52) LMNAALDH1A1HPGDALOX15HSD17B10
SCHEMBL2095733 0.79 HTR1A (0.50) ESR1ESR2HDAC4HDAC2HDAC8
SCHEMBL3681666 0.79 ESR1 (0.44) ABCB1LMNAKDM4EALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7468464-B2 Resorcinol derivatives for skin UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2008-12-23 US claimed
US-20080131382-A1 Novel Resorcinol Derivatives for Skin UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2008-06-05 US claimed
CN-101184722-B Novel resorcinol derivatives for skin UNILEVER NV 2011-06-22 CN disclosed
US-7468464-B2 Resorcinol derivatives for skin UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2008-12-23 US disclosed
EP-1861353-B1 NOVEL RESORCINOL DERIVATIVES FOR SKIN UNILEVER PLC (GB) 2008-10-08 EP disclosed
US-20080131382-A1 Novel Resorcinol Derivatives for Skin UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2008-06-05 US disclosed
CN-101184722-A Novel resorcinol derivatives for skin UNILEVER HOME & PERSONAL CARE (NL) 2008-05-21 CN disclosed
CN-101175711-A Novel resorcinol derivatives UNILEVER PLC (NL) 2008-05-07 CN disclosed
EP-1861353-A1 NOVEL RESORCINOL DERIVATIVES FOR SKIN UNILEVER PLC (GB) 2007-12-05 EP disclosed
EP-1858835-A1 NOVEL RESORCINOL DERIVATIVES UNILEVER PLC (GB) 2007-11-28 EP disclosed
US-20060210498-A1 Novel resorcinol derivatives for skin UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2006-09-21 US disclosed
WO-2006097224-A1 NOVEL RESORCINOL DERIVATIVES FOR SKIN UNILEVER PLC (GB) 2006-09-21 WO disclosed
WO-2006097223-A1 NOVEL RESORCINOL DERIVATIVES UNILEVER PLC (GB) 2006-09-21 WO disclosed
US-20060210497-A1 Novel resorcinol derivatives UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2006-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080131382-A1 Novel Resorcinol Derivatives for Skin NR1H2, CYP1B1, NR0B1 ABCB1 1973/4885TP53 4288/4885LMNA 888/4885
US-20060210498-A1 Novel resorcinol derivatives for skin NR1H2, CYP1B1, NR0B1 ABCB1 1973/4885TP53 4288/4885LMNA 888/4885
US-20060210497-A1 Novel resorcinol derivatives NR1H2, DEGS1, NR1H3 ABCB1 2025/4885TP53 4391/4885LMNA 510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.