Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 4/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608138 | 1.00 | MAPT (0.64) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL4448153 | 0.82 | SLC5A1 (0.48) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL4448152 | 0.82 | SLC5A1 (0.48) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL11727556 | 0.81 | LMNA (0.57) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL11727563 | 0.81 | LMNA (0.57) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL4453938 | 0.80 | AURKA (0.65) | MAPTNPC1RAB9AMAOBMAOA | |
| SCHEMBL4453943 | 0.80 | AURKA (0.65) | MAPTNPC1RAB9AMAOBMAOA | |
| SCHEMBL8146385 | 0.80 | MAPT (0.62) | MAPTNPC1RAB9AKMT2AMAOB | |
| SCHEMBL1938583 | 0.79 | ABCG2 (0.59) | MAPTNPC1RAB9AMAOAABCG2 | |
| SCHEMBL1938581 | 0.79 | ABCG2 (0.59) | MAPTNPC1RAB9AMAOAABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | claimed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | claimed |