Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608279 | 0.82 | DRD2 (0.53) | DRD2DRD3HTR1ADRD5HTR2A | |
| SCHEMBL2437211 | 0.75 | DRD2 (0.49) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL18737492 | 0.72 | DRD2 (0.51) | KCNH2ALDH1A1LMNATSHRDRD2 | |
| Fumaric Acid SCHEMBL27571134 | 0.70 | DRD2 (0.46) | SMN1; SMN2LMNATSHRDRD2DRD3 | |
| SCHEMBL4607941 | 0.70 | GRIN2B (0.47) | KCNH2ALDH1A1 | |
| SCHEMBL5170879 | 0.70 | DRD2 (0.51) | DRD2DRD3 | |
| Abt-925 SCHEMBL1043144 | 0.70 | DRD2 (0.67) | DRD2DRD3 | |
| SCHEMBL13312913 | 0.69 | DRD3 (0.46) | KCNH2DRD2DRD3 | |
| SCHEMBL16019525 | 0.69 | NOTUM (0.56) | KCNH2SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL12959304 | 0.68 | DRD2 (0.49) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | claimed |
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | disclosed |