Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674560 | 0.85 | DRD2 (0.62) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL4610058 | 0.83 | DHFR (0.46) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL4610053 | 0.83 | DHFR (0.46) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4609800 | 0.83 | DHFR (0.45) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7070981 | 0.83 | DHFR (0.45) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4609803 | 0.83 | DHFR (0.45) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7070972 | 0.83 | DHFR (0.45) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL4608233 | 0.82 | KCNH2 (0.40) | DRD2DRD3HTR7DRD5HTR1A | |
| SCHEMBL2437211 | 0.81 | DRD2 (0.49) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7047571 | 0.80 | DRD2 (0.64) | DRD2DRD3ADRA1AHRH4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | claimed |
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | disclosed |