Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 16/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609000 | 0.90 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5MC4R | |
| SCHEMBL4610088 | 0.88 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5AKR1C3 | |
| SCHEMBL4610011 | 0.85 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3GRM5AKR1C3 | |
| SCHEMBL4608750 | 0.84 | GRM5 (0.56) | SLC6A2SLC6A4SLC6A3GRM5 | |
| SCHEMBL4608926 | 0.83 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5AKR1C3 | |
| SCHEMBL1902180 | 0.83 | KMT2A (0.42) | SLC6A2SLC6A4SLC6A3GRM5MC4R | |
| SCHEMBL4610865 | 0.83 | IDO1 (0.42) | SLC6A2SLC6A4SLC6A3GRM5AKR1C3 | |
| SCHEMBL4609669 | 0.82 | GRM5 (0.56) | SLC6A2SLC6A4SLC6A3GRM5MC4R | |
| SCHEMBL4610103 | 0.81 | GRM5 (0.59) | GRM5 | |
| SCHEMBL4608127 | 0.79 | GRM5 (0.41) | SLC6A2SLC6A4SLC6A3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |