Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 6/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4610011 | 0.89 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3GRM5MAPT | |
| SCHEMBL4608926 | 0.88 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5DRD2 | |
| SCHEMBL4610088 | 0.84 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5DRD4 | |
| SCHEMBL4608428 | 0.83 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3GRM5MC4R | |
| SCHEMBL4609000 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GRM5NPY2R | |
| SCHEMBL4608871 | 0.79 | KDM4E (0.41) | SLC6A2SLC6A4SLC6A3GRM5MAPT | |
| SCHEMBL4608750 | 0.78 | GRM5 (0.56) | SLC6A2SLC6A4SLC6A3GRM5 | |
| SCHEMBL4609669 | 0.78 | GRM5 (0.56) | KMT2ASLC6A2SLC6A4SLC6A3GRM5 | |
| SCHEMBL4608995 | 0.78 | GRM5 (0.45) | SLC6A2SLC6A4SLC6A3GRM5ALDH1A1 | |
| SCHEMBL4610110 | 0.78 | GRM5 (0.42) | KMT2ASLC6A2SLC6A4SLC6A3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935703-B2 | Piperazines and piperidines as Mglur5 potentiators | ASTRAZENECA AB (SE) | 2011-05-03 | — | — | US | disclosed |
| US-20090023711-A1 | Piperazines and Piperidines as Mglur5 Potentiators | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023711-A1 | Piperazines and Piperidines as Mglur5 Potentiators | GRM5, GRM1, GRIN1 | KMT2A 1247/4885SLC6A2 509/4885SLC6A4 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.