Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4610133 | 0.90 | HRH3 (0.44) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4607800 | 0.88 | HRH3 (0.39) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4609186 | 0.88 | HRH3 (0.52) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL14538706 | 0.87 | HRH3 (0.38) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4654451 | 0.86 | L3MBTL3 (0.38) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4608914 | 0.86 | SLC6A3 (0.47) | HRH3L3MBTL3L3MBTL1MBTD1SLC6A3 | |
| SCHEMBL14538837 | 0.85 | L3MBTL3 (0.47) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL14538733 | 0.85 | L3MBTL3 (0.47) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4609625 | 0.84 | HRH3 (0.40) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL14538735 | 0.84 | L3MBTL3 (0.48) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |