SCHEMBL4608649

SCHEMBL4608649

O=C1CCC(Cc2ccccc2)(C(=O)OCc2ccccc2)O1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.50
CRBN Q96SW2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6297349 0.93 DDB1 (0.44) DDB1CRBN
SCHEMBL6299054 0.85 DDB1 (0.46) DDB1CRBN
SCHEMBL3524295 0.83 MAOA (0.38) DDB1CRBN
SCHEMBL3524293 0.83 MAOA (0.38) DDB1CRBN
SCHEMBL4272254 0.80 DDB1 (0.51) DDB1CRBN
SCHEMBL27675507 0.80 DDB1 (0.51) DDB1CRBN
SCHEMBL4609023 0.80 DDB1 (0.54) DDB1CRBN
SCHEMBL10554096 0.78 DDB1 (0.47) DDB1CRBN
SCHEMBL10555922 0.78 DDB1 (0.47) DDB1CRBN
SCHEMBL20156647 0.78 DDB1 (0.46) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1541174-A1 DRUG OR COSMETIC Ishibashi, Michio (JP) 2005-06-15 EP claimed
EP-1950563-A2 Method for screening for a substance for promoting regeneration of macrophages Ishibashi, Michio (JP) 2008-07-30 EP disclosed
US-20060014709-A1 Drug or cosmetic ISHIBASHI MICHIO 2006-01-19 US disclosed
US-20050143453-A1 Selective preventing and therapeutic agents for progressive lesion after organic damage ISHIBASHI MICHIO (JP) 2005-06-30 US disclosed
EP-1541174-A1 DRUG OR COSMETIC Ishibashi, Michio (JP) 2005-06-15 EP disclosed
US-6878745-B2 Selective preventives/remedies for progressive lesions after organ damage Ishibashi, Michio (JP) 2005-04-12 US disclosed
US-20030181506-A1 Selective preventives/remedies for progressive lesions after organ damage ISHIBASHI, MICHIO (JP) 2003-09-25 US disclosed
EP-1277747-A1 SELECTIVE PREVENTIVES/REMEDIES FOR PROGRESSIVE LESIONS AFTER ORGAN DAMAGE Ishibashi, Michio (JP) 2003-01-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030181506-A1 Selective preventives/remedies for progressive lesions after organ damage CCL11, CD68, CCL2 DDB1 495/4885CRBN 4234/4885
US-20060014709-A1 Drug or cosmetic CTSA, MSR1, CD68 DDB1 1553/4885CRBN 3936/4885
US-20050143453-A1 Selective preventing and therapeutic agents for progressive lesion after organic damage CD68, MSR1, CCL2 DDB1 578/4885CRBN 3895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.