Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105626 | 0.91 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL2103249 | 0.75 | IDH1 (0.31) | — | |
| SCHEMBL7258032 | 0.74 | CA12 (0.32) | — | |
| SCHEMBL22075884 | 0.74 | TSHR (0.35) | — | |
| SCHEMBL2104237 | 0.68 | KDM4E (0.31) | — | |
| SCHEMBL224515 | 0.66 | KDM4E (0.30) | — | |
| SCHEMBL7052559 | 0.61 | TAAR1 (0.48) | CXCR2RIPK1 | |
| SCHEMBL20451474 | 0.59 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL13466803 | 0.59 | RIPK1 (0.40) | CXCR2RIPK1 | |
| SCHEMBL4429227 | 0.58 | RIPK1 (0.48) | CXCR2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |