Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | GALR1 | P47211 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596282 | 0.75 | AR (0.37) | NOTUMHSD11B1ARSCN9APSMB8 | |
| SCHEMBL4609397 | 0.73 | NOTUM (0.37) | NOTUMHSD11B1ARSCN9APSMB8 | |
| SCHEMBL197671 | 0.71 | HSD11B1 (0.56) | NOTUMHSD11B1ARPSMB8ALDH1A1 | |
| SCHEMBL8022901 | 0.69 | HSD11B1 (0.54) | NOTUMHSD11B1ARPSMB8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29010139 | 0.69 | HSD11B1 (0.54) | NOTUMHSD11B1ARPSMB8ALDH1A1 | |
| SCHEMBL4595505 | 0.68 | AR (0.34) | NOTUMHSD11B1ARSCN9APSMB8 | |
| SCHEMBL4223592 | 0.67 | HTR2C (0.40) | NOTUMHSD11B1ARSCN9AALDH1A1 | |
| SCHEMBL16193459 | 0.66 | CES1 (0.40) | NOTUMHSD11B1ARSCN9APSMB8 | |
| SCHEMBL18646126 | 0.66 | GALR1 (0.41) | NOTUMHSD11B1ARSCN9APSMB8 | |
| SCHEMBL15540806 | 0.66 | HSD11B1 (0.47) | NOTUMHSD11B1ARPSMB8GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |