Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609563 | 0.84 | NPSR1 (0.46) | CHRNB4CHRNA3CHRNA7MAP4K4CYP1A2 | |
| SCHEMBL411023 | 0.79 | BACE1 (0.44) | MAP4K4CYP1A2KCNH2MINK1TNIK | |
| SCHEMBL3143008 | 0.76 | CHRNB4 (0.39) | CHRNB4CHRNA3CHRNA7MAP4K4KCNH2 | |
| Hydrochloric Acid SCHEMBL3773488 | 0.75 | CHRNB4 (0.39) | CHRNB4CHRNA3CHRNA7MAP4K4KCNH2 | |
| Hydrochloric Acid SCHEMBL3773493 | 0.74 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNA7KCNH2FFAR4 | |
| SCHEMBL3137211 | 0.70 | FFAR4 (0.38) | CHRNB4CHRNA3CHRNA7MAP4K4FFAR4 | |
| SCHEMBL3137206 | 0.70 | FFAR4 (0.38) | CHRNB4CHRNA3CHRNA7MAP4K4FFAR4 | |
| SCHEMBL16879689 | 0.65 | GSTP1 (0.55) | CYP1A2NPSR1MEN1NPC1RAB9A | |
| SCHEMBL3875252 | 0.65 | CYP11B2 (0.55) | CYP1A2PTGS2 | |
| SCHEMBL3550859 | 0.63 | AHR (0.42) | MAP4K4CYP1A2KCNH2MINK1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-A1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007085750-A1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2007-08-02 | — | — | WO | disclosed |