Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CLPP | Q16740 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611492 | 0.86 | NPC1 (0.34) | NPC1RAB9AANPEPSMN1; SMN2 | |
| SCHEMBL4612091 | 0.81 | GABRA1 (0.38) | NPC1RAB9AANPEPSMN1; SMN2 | |
| SCHEMBL4610957 | 0.80 | NPC1 (0.32) | NPC1RAB9AANPEPSMN1; SMN2 | |
| SCHEMBL952735 | 0.80 | PDCD1 (0.38) | NPC1RAB9APDCD1CD274KMT2A | |
| SCHEMBL952736 | 0.80 | PDCD1 (0.38) | NPC1RAB9APDCD1CD274KMT2A | |
| SCHEMBL4610942 | 0.78 | CNR2 (0.36) | NPC1RAB9APPARGPPARASMN1; SMN2 | |
| SCHEMBL4610430 | 0.78 | KDM4E (0.42) | ANPEPALDH1A1 | |
| SCHEMBL4609937 | 0.78 | TSHR (0.34) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7170211 | 0.71 | PDCD1 (0.46) | RAB9APDCD1CD274KMT2ADPP4 | |
| SCHEMBL1024640 | 0.71 | PDCD1 (0.46) | PDCD1CD274KMT2ADPP4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |