Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4610957 | 0.89 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL4611492 | 0.87 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL4612091 | 0.82 | GABRA1 (0.38) | NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL952652 | 0.79 | TSHR (0.39) | TSHR | |
| SCHEMBL952653 | 0.79 | TSHR (0.39) | TSHR | |
| SCHEMBL4610942 | 0.79 | CNR2 (0.36) | NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL4610430 | 0.79 | KDM4E (0.42) | TSHR | |
| SCHEMBL4609728 | 0.78 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL955537 | 0.74 | TSHR (0.44) | TSHR | |
| SCHEMBL953307 | 0.69 | TSHR (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |