Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56220 | 0.83 | STS (0.56) | MEN1KMT2ACA1CA12CA7 | |
| SCHEMBL11953320 | 0.80 | SMN1; SMN2 (0.61) | MEN1KMT2ACA2CA1NPSR1 | |
| SCHEMBL55795 | 0.78 | STS (0.61) | MEN1KMT2ACA1CA12CA7 | |
| SCHEMBL3811125 | 0.77 | CA12 (0.59) | KMT2ACA2CA1CA12CA7 | |
| SCHEMBL11946070 | 0.77 | NSD2 (0.51) | CA2CA1CA12CA7CA14 | |
| SCHEMBL65669 | 0.77 | NPY5R (0.39) | MEN1KMT2ANPSR1 | |
| SCHEMBL14721003 | 0.76 | CXCR4 (0.58) | MEN1KMT2ANPSR1HDAC3HDAC4 | |
| SCHEMBL27890613 | 0.75 | NSD2 (0.53) | CA2CA1CA12CA7CA14 | |
| SCHEMBL1189971 | 0.74 | ACHE (0.60) | MEN1KMT2ANPSR1 | |
| SCHEMBL16269315 | 0.74 | ACHE (0.60) | MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948597-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007050522-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-03 | — | — | WO | disclosed |