Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.48 |
| ▸ | PTPRB | P23467 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56220 | 0.93 | STS (0.56) | STSKDM4EPKMTGFBR1GPR119 | |
| SCHEMBL11953320 | 0.83 | SMN1; SMN2 (0.61) | CA1CA7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7985552 | 0.82 | KDM4E (0.69) | STSKDM4EPKMTGFBR1GPR119 | |
| SCHEMBL20137861 | 0.82 | STS (0.68) | STSKDM4EPKMTGFBR1GPR119 | |
| SCHEMBL56477 | 0.82 | TGFBR1 (0.59) | STSKDM4EPKMTGFBR1GPR119 | |
| SCHEMBL616004 | 0.81 | STS (0.60) | STSKDM4EPKMGPR119KEAP1 | |
| SCHEMBL785861 | 0.80 | KDM4E (0.60) | STSKDM4EPKMTGFBR1GPR119 | |
| SCHEMBL12804554 | 0.80 | NPSR1 (0.68) | STSKDM4EPKMGPR119KEAP1 | |
| SCHEMBL5266529 | 0.79 | KDM4E (0.61) | STSKDM4EPKMGPR119KEAP1 | |
| SCHEMBL3923737 | 0.79 | KDM4E (0.64) | STSKDM4EPKMGPR119LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102659668-B | Method for synthesizing 1-alkyl-piperidine-4-sulfonyl benzylamine | SUZHOU HANDE CHUANGHONG BIOCHEMICAL TECHNOLOGY CO LTD | 2014-04-09 | — | — | CN | claimed |
| CN-102659668-A | Method for synthesizing 1-alkyl-piperidine-4-sulfonyl benzylamine | SUZHOU HANDE CHUANGHONG BIOCHEMICAL TECHNOLOGY CO LTD | 2012-09-12 | — | — | CN | claimed |
| CN-102659668-B | Method for synthesizing 1-alkyl-piperidine-4-sulfonyl benzylamine | SUZHOU HANDE CHUANGHONG BIOCHEMICAL TECHNOLOGY CO LTD | 2014-04-09 | — | — | CN | disclosed |
| CN-102659668-A | Method for synthesizing 1-alkyl-piperidine-4-sulfonyl benzylamine | SUZHOU HANDE CHUANGHONG BIOCHEMICAL TECHNOLOGY CO LTD | 2012-09-12 | — | — | CN | disclosed |
| US-8129546-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129546-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129546-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110077269-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110077269-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110077269-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | US | disclosed |
| US-7842819-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842819-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842819-B2 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-20070203122-A1 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-30 | — | — | US | disclosed |
| US-20070203122-A1 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-30 | — | — | US | disclosed |
| US-20070203122-A1 | Derivatives for modulation of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203122-A1 | Derivatives for modulation of ion channels | TRPV1, TRPA1, TRPV2 | STS 1857/4885KDM4E 3285/4885PKM 2783/4885 |
| US-20110077269-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | TRPV1, TRPA1, TRPV2 | STS 1857/4885KDM4E 3285/4885PKM 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.